Sildenafil

Important Safety Information

Read the following safety information carefully before using sildenafil. Discuss any questions or concerns with your healthcare provider.

Safety Checklist

Do NOT take sildenafil if you:

  • Take nitrate medications for chest pain or heart problems (such as nitroglycerin, isosorbide mononitrate, or isosorbide dinitrate). Taking sildenafil with nitrates can cause a sudden, unsafe drop in blood pressure.
  • Use recreational drugs called “poppers” (such as amyl nitrate or amyl nitrite, butyl nitrate).
  • Take riociguat (Adempas), a guanylate cyclase stimulator used for pulmonary arterial hypertension.

Who Should Avoid Sildenafil

Tell your healthcare provider if you have any of the following conditions before taking sildenafil:

  • Heart problems such as angina, heart failure, irregular heartbeat, or a history of heart attack.
  • Stroke within the last 6 months.
  • Low or high blood pressure (hypotension or hypertension).
  • A condition affecting the shape of the penis (such as Peyronie’s disease, cavernosal fibrosis, or angulation).
  • Blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia.
  • Bleeding disorders.
  • Stomach ulcers or other bleeding problems.
  • Retinitis pigmentosa or other eye problems.
  • Liver or kidney disease.
  • Allergy to sildenafil or any ingredients in the medication.

Medication Interactions

Tell your healthcare provider about all medications you take, including prescription and over-the-counter drugs, vitamins, and herbal supplements. Sildenafil may interact with:

  • Alpha-blockers: Used for prostate problems or high blood pressure. Taking sildenafil with alpha-blockers can cause a drop in blood pressure.
  • Other PDE5 inhibitors: Such as tadalafil (Cialis) or vardenafil (Levitra). Do not use sildenafil with other PDE5 inhibitors.
  • HIV protease inhibitors: Such as ritonavir. These may increase sildenafil levels in the blood.
  • Certain antibiotics and antifungals: Such as erythromycin, clarithromycin, ketoconazole, and itraconazole.
  • Other blood pressure medications: Sildenafil may add to the blood-pressure-lowering effects of these medications.

How to Use Safely

  • Take sildenafil exactly as prescribed by your healthcare provider.
  • Sildenafil is typically taken about 30 to 60 minutes before sexual activity.
  • Do not take more than one dose in a 24-hour period.
  • Sildenafil can be taken with or without food. A high-fat meal may delay the time it takes to work.
  • Avoid excessive alcohol consumption, which can increase the risk of side effects.
  • Do not combine sildenafil with other erectile dysfunction medications.

Common Side Effects

Common side effects of sildenafil include:

  • Headache
  • Flushing (warmth, redness, or tingly feeling)
  • Upset stomach or indigestion
  • Nasal congestion (stuffy nose)
  • Back pain
  • Muscle pain
  • Dizziness
  • Nausea
  • Rash

Serious Side Effects

Seek immediate medical attention if you experience any of the following:

  • Priapism: An erection that lasts more than 4 hours. This is a medical emergency that can cause permanent damage to the penis if not treated immediately.
  • Sudden vision loss: In one or both eyes. This may be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy (NAION).
  • Sudden hearing loss: Sometimes with ringing in the ears (tinnitus) or dizziness.
  • Heart attack symptoms: Chest pain, pain spreading to the jaw or shoulder, nausea, sweating.
  • Allergic reaction: Hives, difficulty breathing, swelling of the face, lips, tongue, or throat.
  • Severe dizziness or fainting.

Frequently Asked Questions

How long does sildenafil last?

Sildenafil typically lasts 4 to 6 hours. The effects may vary from person to person depending on dosage, metabolism, and other factors. It does not cause a constant erection; sexual stimulation is still required.

Is sildenafil safe?

Sildenafil is generally safe when taken as prescribed by a healthcare provider. It has been used by millions of men worldwide. However, it is not safe for everyone, especially those taking nitrates or certain other medications. Always consult your provider to determine if sildenafil is right for you.

Can I take sildenafil with blood pressure medications?

Sildenafil can interact with some blood pressure medications and cause your blood pressure to drop too low. Tell your healthcare provider about all medications you take, especially alpha-blockers and nitrates. Your provider can advise whether it is safe for you.

Can I take supplements with sildenafil?

Some supplements may interact with sildenafil. Always inform your healthcare provider about any supplements, vitamins, or herbal products you are taking. Avoid combining sildenafil with other supplements marketed for erectile dysfunction.

Telehealth Safety Note

Through InstaRx, a licensed healthcare provider will review your medical history and current medications to determine if sildenafil is appropriate and safe for you. It is important to provide complete and accurate information during your consultation. If your health status changes or you experience side effects, contact your healthcare provider promptly through the InstaRx platform.